We will create a framework for generating in-depth genomic, molecular, and drug-related data that can be used to model the host–pathogen immunity gut–brain interactions in a whole organism. The long-term goal is to understand the mechanisms for tolerance to pathogens and to identify novel molecules that can be used therapeutically to reduce toxic infection in trauma patients.
Chang, C., et al. 2018. "SOST/Sclerostin Improves Post-Traumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury." Journal of Bone and Mineral Research 33(6): 1105–1113. doi: 10.1002/jbmr.3397. LLNL-JRNL-723818.
Sebastian, A. and G. Loots. 2017. "Genetics of Sost/SOST in Sclerosteosis and van Buchem Disease Animal Models." Metabolism 80: 38–47. doi: 10.1016/j.metabol.2017.10.005. LLNL-JRNL-730352.
Sebastian, A., et al. 2018. "Global Gene Expression Analysis Identifies Mef2c as a Potential Player in Wnt16-mediated Transcriptional Regulation." Gene 675: 312–321. doi: 10.1016/j.gene.2018.06.079. LLNL-JRNL-751700.
——— . 2018. "Comparative Transcriptomics of STR/ort and MRL/MpJ Joints Identifies Mamdc2 and Pxdn as Potential Biomarkers of Post-Traumatic Osteoarthritis." International Journal of Molecular Science 19: 2657. LLNL-JRNL-747404.