##  [Profiling Neurological Consequences and Susceptible Populations of Chronic Opioid Use](/archives/ldrd-annual-2020/project-hightlights/chemical-biological-countermeasures/profiling-neurological-consequences-and-susceptible) 

## Heather Enright | 20-ERD-009

### Executive Summary

We will establish a unique approach that leverages Lawrence Livermore National Laboratory's capabilities (accelerator mass spectrometry and brain-on-chip) to evaluate human-relevant neurological reactions to exposure to fentanyl. Once established, our approach provides a pipeline to evaluate any compound of national interest as well as any potential treatments to mitigate the effects as a result of exposure.

### Publications, Presentations, and Patents

Enright, H. 2020. "Functional and transcriptional characterization of complex neuronal co-cultures." *Sci. Rep.* 10. doi:10.1038/s41598-020-67691-2. LLNL-JRNL-767110

Lam, D., et al. 2020. "Cellular, Molecular and Functional Changes in the Brain Following Acute and Chronic Fentanyl Exposure: Effect of Age and Gender." 2020 Military Health System Research Symposium. LLNL-ABS-807371

Mendez, M., et al. 2020. "Tracking Acute and Chronic Fentanyl Exposure Through the Gut Microbiome." Military Health System Research Symposium. LLNL-ABS-807369