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  5. Direct Visualization of Structural Maintenance of Chromosomes by Protein-Mediated Loop Extrusion Using High-Speed Atomic Force Microscopy

Direct Visualization of Structural Maintenance of Chromosomes by Protein-Mediated Loop Extrusion Using High-Speed Atomic Force Microscopy

Yuliang Zhang | 20-LW-040

Executive Summary

We will use high-speed atomic force microscopy (a cutting-edge technology to closely observe individual molecules at submolecular spatial resolution and subnanosecond time resolution) to visualize for the first time how certain proteins are responsible for packing deoxyribonucleic acid in chromosomes. This research will significantly advance our understanding of genetics.