Eavesdropping on Cancer: Developing Blood-Based Exosome Diagnostics

Nicholas Hum | 21-LW-028

Executive Summary

We aim to develop an innovative exosome-based diagnostic method to detect the intercellular communication between all cells in a host animal in response to the presence and progression of lung cancer. This technology will have wide applications beyond cancer research to provide early diagnostic methods to many disease states and health challenges.

Publications, Presentations, and Patents

Hum, Nicholas R., Aimy Sebastian, Kelly A. Martin, Naiomy D. Rios-Arce, Sean F. Gilmore, David M. Gravano, Elizabeth K. Wheeler, Matthew A. Coleman, and Gabriela G. Loots. 2022. "IL-17A Increases Doxorubicin Efficacy in Triple Negative Breast Cancer." Frontiers in Oncology 12: Medium: X. https://doi.org/10.3389/fonc.2022.928474. https://www.osti.gov/biblio/1876525.

Hum, Nicholas R., Cesar Morfin, Stephen P. Wilson, Deepa Murugesh, Aimy Sebastian, and Gabriela G. Loots. “Defining Cellular Complexity of Mesenchymal Lineage Derived Cells in the Adult Murine Long Bones Using Single-cell Transcriptional Profiling and Bone-targeted Cre-based Lineage Tracing.” Abstract & Poster. American Society for Bone and Mineral Research Annual Meeting. September 2022.

Hum, Nicholas R., Nicole F. Leon, Aimy Sebastian, Kelly A. Martin, and Gabriela G. Loots. “Molecular Characterization of the Effects of Cancer Exosomes on Murine Lung Cancer Tumors.” Abstract & Poster. American Association of Cancer Research Annual Meeting. April 2022.