Do Reprogrammed Brain Cells Hold the Key to Healing Damaged Networks After Traumatic Brain Injury?
Doris Lam | 21-LW-014
We will determine if new neurons from reprogrammed human astrocytes (central nervous system cells) can withstand brain injuries, integrate into existing neural networks, and re-establish brain connectivity in traumatic brain injury patients. Our research will inform treatments to improve mental and physical health and potentially alleviate financial and long-term care burdens for injured military personnel and patients with acute brain injuries, Alzheimer’s, or Parkinson’s diseases.
Publications, Presentations, and Patents
Lam, D., C. Bogguri, J.Cadena, A. Ladd, A Sebastian, H.A Enright, and N.O Fischer. "Adapting The Brain-on-a-chip System To Evaluate Whether Reprogramming Astrocytes Hold The Key To Healing Damaged Neural Networks." In 2021 Neurotrauma, July 11-14, 2021.
Lam, D., N. O. Fischer, and H. A. Enright. 2021. "Probing function in 3D neuronal cultures: A survey of 3D multielectrode array advances." Curr Opin Pharmacol 60: 255-260. https://doi.org/10.1016/j.coph.2021.08.003. https://www.ncbi.nlm.nih.gov/pubmed/34481335.