Do Reprogrammed Brain Cells Hold the Key to Healing Damaged Networks After Traumatic Brain Injury?

Doris Lam | 21-LW-014

Executive Summary

We will determine if new neurons from reprogrammed human astrocytes (central nervous system cells) can withstand brain injuries, integrate into existing neural networks, and re-establish brain connectivity in traumatic brain injury patients. Our research will inform treatments to improve mental and physical health and potentially alleviate financial and long-term care burdens for injured military personnel and patients with acute brain injuries, Alzheimer’s, or Parkinson’s diseases.

Publications, Presentations, and Patents

Lam, D., C. Bogguri, J.Cadena, A. Ladd, A Sebastian, H.A Enright, and N.O Fischer. "Adapting The Brain-on-a-chip System To Evaluate Whether Reprogramming Astrocytes Hold The Key To Healing Damaged Neural Networks." In 2021 Neurotrauma, July 11-14, 2021.

Lam, D., N. O. Fischer, and H. A. Enright. 2021. "Probing function in 3D neuronal cultures: A survey of 3D multielectrode array advances." Curr Opin Pharmacol 60: 255-260.