Elizabeth Wheeler | 19-SI-003
Executive Summary
We will develop a bioprinted, ex vivo, human-relevant, three-dimensional cancerous tumor model that enables spatio-temporal control and measurement of multiple tissue, cellular, and molecular components that drive tumor growth. We will study the effect of the immune system and drugs to modulate tumor microenvironment, growth, and regression to gain data to calibrate computational models, predictions, and personalized therapeutics.
Publications, Presentations, and Patents
Hum, N. R., et al. 2020a. "Epithelial-mesenchymal hybrid population changes from monolayer, spheroid, and tumoroid ex vivo culture of syngeneic murine mammary tumors." AACR Annual Meeting, Philadelphia, PA, April and June 2020. LLNL-POST-811104
——— 2020b. "Epithelial-mesenchymal hybrid populations changes from monolayer, spheroid, and tumoroid ex vivo culture of syngeneic murine mammary tumors." American Association for Cancer Research 13(2), 114-117. doi:10.1016/j.pan.2013.01.004. LLNL-ABS-798441
Wheeler, E. 2020a. "Comparative Molecular Analysis of Cancer Behavior Cultured In Vitro, In Vivo, and Ex Vivo." CANCERS 12. doi:10.3390/cancers12030690. LLNL-JRNL-782408
——— 2020b. "Macromolecular gelatin properties affect fibrin microarchitecture and tumor spheroid behavior in fibrin-gelatin gels." Biomaterials 250. doi:10.1016/j.biomaterials.2020.120035. LLNL-JRNL-800043
——— 2020c. "Single-Cell Transcriptomic Analysis of Tumor-Derived Fibroblasts and Normal Tissue-Resident Fibroblasts Reveals Fibroblast Heterogeneity in Breast Cancer." CANCERS. 12. doi:10.3390/cancers12051307 LLNL-JRNL-807797
