Lawrence Livermore National Laboratory



Elizabeth Wheeler

Executive Summary

We will develop a bio-printed, ex vivo, human-relevant, three-dimensional cancerous tumor model that enables spatio-temporal control and measurement of multiple tissue, cellular, and molecular components that drive tumor growth. We will study the effect of the immune system and drugs to modulate tumor microenvironment, growth, and regression to gain data to calibrate computational models, predictions, and personalized therapeutics.

Publications, Presentations, Etc.

Dubbin, K., et al. 2019. "Bioprinted Microenvironment for Tumor-Immune System Modeling." Gordon Research Conference, Biomaterials and Tissue Engineering, Castelldefels, Spain, July/August 2019. LLNL-ABS-769064.

Hum, N., et al. 2019. "RNA-seq Comparisons of in vitro and in vivo Cancer Model Platforms: Monolayer, Spheroids, Immunodeficient, and Syngeneic Mouse Model." Livermore, CA, March 2019. LLNL-POST-770541.

——— . 2019 "Characterization of the Tumor Microenvironment Using Single Cell Transcriptomics of Triple Negative Breast Cancer Allografts Treated with Doxorubicin." American Association of Cancer Research Annual Meeting 2019, Atlanta, GA, March/April, 2019. doi:10.1158/1538-7445.AM2019-130. LLNL-ABS-762099.

——— . 2019. "Characterization of the Tumor Microenvironment Using Single Cell Transcriptomics of Triple Negative Breast Cancer Allografts Treated with Doxorubicin." American Association of Cancer Research Annual Meeting 2019, Atlanta, GA, March/April, 2019. doi: 10.1158/1538-7445.AM2019-130. LLNL-POST-770782.

Hynes, W., et al. 2018. “Development of a Dynamic Bioprinted Tumor Model.” Biomedical Engineering Society (BMES) Annual Meeting, Atlanta, GA, October 2018. LLNL-POST-759650 and LLNL-ABS-750637.

——— . 2019 "Development of a Dynamic Bioprinted Tumor Model for Comparison to Other in vitro Methods." Biomedical Engineering Society (BMES) Annual Meeting, Philadelphia, PA, October 2019. LLNL-ABS-750637.

Moya, M. and K. Dubbin. 2019. "Bioprinting Tumor Microenvironments." Livermore, CA, September 2019. LLNL-PRES-790238.