Engineered Human Vascular Models to Study Endothelial Dysfunction in Infectious Disease

Executive Summary

We will establish the first human in-vitro model to interrogate the interactions of pathogens, the innate immune system, and endothelium that causes vasculopathy. An infectable, physiologically relevant, human in-vitro model is critical to understand the pathogenesis of emerging pathogens and to develop effective countermeasures.

Publications, Presentations, and Patents

Adorno, J. et al. "Understanding Endothelial Function in SARS-CoV-2." 2022. LLNL Research Slam, September, 2022. LLNL-PRES-837890.