Fungal Pneumonia: Understanding Immune Vulnerabilities that Cause Valley Fever

Executive Summary

We will establish an integrated, multi-disciplinary, fungal host-pathogen biology platform to obtain mechanistic insights into how our immune system either clears a Coccidioides respiratory infection or succumbs to its most severe, fatal outcomes. By expanding our understanding of respiratory threats which currently have no effective treatment, we can more rapidly develop effective countermeasures.