Graph-Based Modeling for Detection and Tracking of Sarin-Surrogate-Induced Neurotoxicity using a human-relevant in vitro brain model

Executive Summary

We will advance the computational analytical capabilities of "brain-on-a-chip" systems to detect neural dysfunction and degeneration, two key mechanisms that occur in the brain following neurotoxicity, injury, and disease. With the proposed computational tools, we will study whether neurotoxicity is prevented by a existing therapeutic agent and a promising therapeutic that is a central nervous system reactivator that can cross the blood brain barrier.