High-Resolution Bioprinted Hierarchical Lung Tissue Model for Studying Respiratory Threats

Executive Summary

We will integrate two advanced, three-dimensional bioprinting processes with biocompatible photopolymer resins to build models that realistically represent the physiology of human lung alveolar and microcapillary structures. Once loaded with human cells, the platform will enable investigations of host-pathogen interactions, as well as rapid development of therapeutics against injury or infection.

Publications, Presentations, and Patents

J. J. Karnes, T. H. Weisgraber, C. C. Cook, D. N. Wang, J. C. Crowhurst, C. A. Fox, B. S. Harris, J. S. Oakdale, R. Faller, and M. Shusteff, “Isolating Chemical Reaction Mechanism as a Variable with Reactive Coarse-Grained Molecular Dynamics: Step-Growth versus Chain-Growth Polymerization,” Macromolecules 2023 56 (6), 2225-2233 DOI: 10.1021/acs.macromol.2c02069

J. Madrid-Wolff, J. Toombs, R. Rizzo, P. Nuñez Bernal, D. Porcincula, R. Walton, B, Wang, F. Kotz-Helmer, Y. Yang, D. Kaplan, Y. S. Zhang, M. Zenobi-Wong, R. R. McLeod, B. Rapp, J. Schwartz, M. Shusteff, H. Talyor, R. Levato, C. Moser, “A review of materials used in tomographic volumetric additive manufacturing.” MRS Communications 13, 764–785 (2023). DOI: 10.1557/s43579-023-00447-x