Profiling Neurological Consequences and Susceptible Populations of Chronic Opioid Use

Executive Summary

We will establish a unique approach that leverages Lawrence Livermore National Laboratory's capabilities (accelerator mass spectrometry and brain-on-chip) to evaluate human-relevant neurological reactions to exposure to fentanyl. Once established, our approach provides a pipeline to evaluate any compound of national interest as well as any potential treatments to mitigate the effects as a result of exposure.

Publications, Presentations, and Patents

Lam D et al 2021. “Probing function in 3D neuronal cultures: a survey of 3D multielectrode array advances.” Curr Opin Pharmacol 60, 255-260. DOI: 10.1016/j.coph.2021.08.003. LLNL-TR-823576.