Antimicrobials for Multi-Drug Resistant Infections for BioResilience, Advancement

Executive Summary

We propose to leverage the analytical expertise of the Forensic Science Center’s scientists and state-of-the-art instrumentation and to utilize an innovative mass spectrometry-based metabolomics analysis method to identify novel antimicrobials from unexplored algal production pond extracts against multi-drug resistant human pathogens. Our goal is to develop a new, higher-probability, unbiased approach to produce what we hope will be the next penicillin antibiotic, and beyond.

Publications, Presentations, and Patents

Colin Ponce and Kourosh Arasteh, “Harnessing the Power of Machine Learning & Mass Spectrometry to Identify Novel Chemicals in Complex Environments”; Gary Trubl and Kourosh Arasteh “Antimicrobials for Multi-drug resistant Infections for Bio-Resilience Advancement (AMIBA)” (Joint Poster Presentation by K. Arasteh, C.V. Ponce, S. Magana-Zook, A. Vu, R. Leif, M. Dreyer, B. Mayer, C.L. Fisher and G. Trubl, K. Arasteh, K. Morrison, C.L Fisher; Defense Threat Reduction Agency, San Francisco, CA, December 6, 2022). IM# LLNL-POST-842918.

Vidia Gokool, “Marine Natural Product Discovery: Exploring the Antimicrobial Activity of Algal Pond Extracts” (oral presentation by V.A. Gokool, G. Trubl, K. Morrison, C. L. Fisher; Gordon Research Seminar on Chemical and Biological Threats, Ventura, CA, March 19, 2023). IM# LLNL-PRES-846540.

Vidia Gokool, “Marine Natural Product Discovery: Exploring the Antimicrobial Activity of Algal Pond Extracts” (Oral Presentation by V.A. Gokool, G. Trubl, K. Morrison, C. L. Fisher; Gordon Research Conference on Chemical and Biological Threats, Ventura, CA, March 21, 2023). IM# LLNL-PRES-846540.

Vidia Gokool, “Marine Natural Product Discovery: Exploring the Antimicrobial Activity of Algal Pond Extracts” (Poster Presentation by V.A. Gokool, G. Trubl, K. Morrison, C. L. Fisher; Gordon Research Seminar on Chemical and Biological Threats, Ventura, CA, March 19, 2023). IM# LLNL-POST-846543.

Vidia Gokool, “Marine Natural Product Discovery: Exploring the Antimicrobial Activity of Algal Pond Extracts” (Poster Presentation by V.A. Gokool, G. Trubl, K. Morrison, C. L. Fisher; Gordon Research Conference on Chemical and Biological Threats, Ventura, CA, March 20-23, 2023). IM# LLNL-POST-846543.

Gary Trubl, “Culture-independent detection of antimicrobials for multi-drug resistant pathogens from unexplored natural ecological assemblages” (Poster Presentation by G. Trubl, V.A. Gokool, K. Arasteh, K. Morrison, C.L. Fisher; Gordon Research Conference on Chemical and Biological Threats, Ventura, CA, March 20-23, 2023) IM# LLNL-POST-846435.

Vidia Gokool, “Marine Natural Product Discovery: Exploring the Antimicrobial Activity of Algal Pond Extracts” (Poster Presentation by V.A. Gokool, G. Trubl, K. Morrison, P. Lane*, T. Lane*, C.L. Fisher; LLNL 2023 Postdoctoral Poster Symposium, Livermore, CA, May 4, 2023). IM# LLNL-POST-846543.

Vidia Gokool, “Marine Natural Product Discovery: Exploring the Antimicrobial Activity of Algal Pond Extracts” (Poster Presentation by V.A. Gokool, G. Trubl, K. Morrison, P. Lane*, T. Lane*, C.L. Fisher; LLNL 2023 BBTD/ NACS Poster Symposium, Livermore, CA, May 16, 2023). IM# LLNL-POST-846543.

Todd Lane*, “Harnessing the Power of Machine Learning & Mass Spectrometry to Identify Antimicrobials for Multi-drug resistant Infections for Bio-Resilience Advancement (AMIBA)” (Poster Presentation by V.A. Gokool, K. Arasteh, G. Trubl, P. Lane*, T.W. Lane*, C.L. Fisher; International Algal Bioproducts, Biomass, Biofuels, and Bioproducts (IABBB); Kona, HI, June 12-15, 2023). IM# LLNL-POST-849552.

Vidia Gokool, “Exploring Algal Pond Extracts: A Potential Source for New Antimicrobial Therapeutics” (Oral Presentation by V.A. Gokool, K. Arasteh, I. Nanji, C.L. Fisher; American Chemical Society Conference, San Francisco, CA, August 14, 2023). IM# LLNL-PRES-853049.

Imaan Nanji, “Investigating the Antimicrobial Activity of Algal Pond Extracts: Harnessing the power of ML/AI to analyze complex mixtures for new bioactive chemicals” (Poster Presentation by I. Nanji, V.A. Gokool, K. Arasteh, C.L. Fisher; Summer 2023 New & Awesome Interns at LLNL & Sandia/CA (SNAILS) Poster Symposium, Livermore, CA, August 24, 2023). IM# LLNL-POST-853471.

*= Sandia National Laboratories