Modulating Guanosine Triphosphate Hydrolysis Provides Novel Therapeutic Option to Treat Cancer and Bacterial Infections

Executive Summary

We will combine supercomputing and cutting-edge experimental techniques to investigate the cell-growth-controlling mechanism of a hydrolyzing protein, which is important because the loss of this mechanism is at the root of approximately 30 percent of human cancers. This work will provide a novel approach to treat cancers by enabling the design of small molecules to restore control of cell growth while avoiding the development of adaptive resistance, and shed light on novel therapeutic options for selected bacterial infections and related diseases.